The bilirubin is caused by the breakdown of haemoglobin of dead red blood cells. In the healthy state, the liver lowers the level of bilirubin in the blood and removes it from the blood through the gallbladder. Liver damage can be diagnosed by blood tests that examine enzymes present in the liver and which increase sharply in case of liver damage. 

Many liver diseases are caused by hard drugs, toxins or an excessive amount of alcohol. Symptoms of liver disease include pain and swelling, chronic fatigue, prickly and sensitive skin, nausea and vomiting.

List Of Types Of Liver Diseases:

• Hepatic encephalopathy
• Hepatitis
• Cirrhosis liver
• Non-Alcoholic Fatty Liver Disease (NAFLD)
• Alcoholic Fatty Liver Disease (AFLD)
• Gilbert’s Syndrome
• Hemochromatosis

CBD As A Natural Treatment For Various Types Of Liver Diseases

Clinical observations have identified the important role that the endocannabinoid system has in the pathophysiology of liver diseases. It has been found that the endocannabinoid system works in an increased way during the development of chronic liver diseases and is also involved in the development of diseases such as fatty liver disease that is not due to alcohol consumption, scar connective tissues (fibrosis), cirrhosis and more.

The endocannabinoid system affects mechanisms responsible for cell damage and death and the inflammatory response during severe liver damage such as an injury that can happen from ischaemia-reperfusion and therefore treatment of a molecule like cannabidiol for liver diseases will prevent cell death, restore scar tissues, calm inflammation, balance blood pressure and lower the level of toxicity in the bloodstream.

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• CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury

• The Endocannabinoid System and liver diseases

• CBD protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

• Therapeutic potential of CBD against ischemia/reperfusion liver injury in rats

Hepatic Encephalopathy (HE)

HE  is a neuropsychiatric condition (which can be reversible) as a result of liver failure (whether insufficiency as a result of a chronic liver disease, or as a result of acute insufficiency). When there is a failure in liver function, toxic substances, which are normally eliminated by the liver, accumulate in the blood, which flows among other things to the brain and interferes with the proper functioning of brain cells. 

The clinical signs can be, among other things, vague consciousness, astrixisis, a phenomenon of tremor in the palms also known as flapping tremor, and a decrease in the level of consciousness up to the floor, cerebral edema, and ultimately death. Hepatic encephalopathy leads to a change in the level of consciousness: One of the early stages is called day-night reversal: A situation in which the patient complains that he tends to sleep during the day and at night stays awake. In addition, there can be a problem with the specific perception (problem copying simple drawings, drawing a line by connecting dots). 

Tepatic encephalopathy is also manifested in physical examination in astericsis, asking the patient to reach forward, and slow and clenched fluctuations are created (this phenomenon can also occur in kidney failure, for example). 

Although hepatic encephalopathy can reflect worsening of existing liver disease, it can also result from a number of other factors. In fact, almost any metabolic problem can cause hepatic encephalopathy – the most common causes are hyponatremia, decreased sodium levels in the blood (as a result of the use of the urinal), hypokalemia (decrease in blood potassium levels), dehydration, alkalosis (increase in the pH level), and kidney failure.

In 1998, a rating for hepatic encephalopathy based on subgroups was proposed:

Type A acute: Encephalopathy linked with acute liver failure Type B – Encephalopathy caused by snath (SHANT – bypass/bridge) between the portal system and the systemic system (without bypass) type C (cirrhosis), encephalopathy occurs as a result of worsening cirrhosis.

Treatment Of Hepatic Encephalopathy

In the bile duct blocking model in mice with HE liver disease, cannabidiol was found to have a strong and positive medical effect. The action of the adenosine receptor A(2) A is decreasing in liver disease and since cannabidiol is an agonist of this receptor CBD treatment will correct the damage caused by the disease by increasing the action of the adenosine receptor. In addition, the findings showed a marked improvement in liver and brain function.

CBD restores liver function to normality, normalizing serotonin level (HT-5) and together with a positive effect on brain function can be a treatment that has a great positive effect on hepatic encephalopathy.

Read More…

• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice

• Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation

• Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

Hepatitis

The hepatitis HCV and HBV viruses are the most common causes of the disease for chronic viral inflammation in the liver. These viruses cause jaundice and liver cancer. While HBV has a vaccine – the HCV virus does not currently have a vaccine. Pharmacological studies conducted by researchers on the properties of cannabidiol have found that it inhibits the distribution of the HCV virus in culture while not inhibiting the distribution of HBV. CBD reduced the division of the virus by 86.4% at a relatively low dose.

The findings reinforce the assessment that CBD may be a natural vaccine that has a strong effect on the HCV bacterium.

Myeloid-derived suppressor cell (MDSCs) cells have received a lot of attention in recent years in research as key cells in the immune system. They are observed at sites in the body that suffer from inflammation and are ability to suppress T-cell activation. In a recent study, researchers examined how CBD’s activation of the honyloid receptor (ion canal) causes the activation of MDSCs that inhibit the destructive action of T cells and thus treat liver diseases. Link.

Cirrhosis Liver

Cirrhosis is a disease of the liver, during which the organ tissue is destroyed and replaced with scar tissue, causing a disruption in blood flow to the liver cells and disrupting the activity of this important organ. The disease is due to complications of hepatitis B or C, excessive consumption of alcohol, poor diet, exposure to toxins, certain parasites, and also due to taking medications such as: Metrodext and more. symptoms of liver liver are: fatigue, loss of appetite, weight loss and nausea. These are caused by impairment of the liver’s ability to regulate the level of dissolves in the blood. Symptoms that appear in later stages of the disease are a tendency to hemorrhaging and blood clotting disorders, ascites, pronounced veins, jaundice and more.

Currently, the damage caused to the liver as a result of cirrosis is irreversible, and the only complete recovery to the disease involves liver transplantation. Although even then the outcome depends on the patient’s condition and the frequency of the gm, early detection can delay the disease and reduce complications.

CBD & Liver Tube Care

The mechanisms by which cannabidiol works in aid of liver function are still not fully clear. Many researchers believe that, as with other inflammatory diseases, here too, endocannabinoid dysfunction plays an important role.

In studies conducted in 2005 and 2011, CBD has been found to help treat liver diseases by eliminating hepatic stellate cells in the liver HSC that cause tissue scarring, and finally cannabidiol has been found to be effective in reducing nerve damage to cells by HSC and suppressing inflammation of the liver tissue as a result of impairment due to drinking alcohol or not alcohol.

Read More…

• Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Non-Alcoholic Fatty Liver Disease (NAFLD)

Fatty liver may be caused by obesity, diabetes and heart disease. Fatty liver disease is caused by alcohol consumption caused by an increase in the concentration of fat cells in the liver and the appearance of scar tissues that impair the functioning of other liver cells. Studies in mice and rats using CBD provide have found that cannabidiol has a protective effect on liver cells as well as lowering liver fat levels.

Alcoholic Fatty Liver Disease (AFLD)

The liver may be particularly damaged by excessive alcohol. Alcohol addiction causes liver damage. Since it is the only organ in the body that performs the metabolism of ethanol, liver damage is a life-threatening injury. At a young age the liver is strong and you manage to break down all the alcohol you drink but over time the liver fails to break down the alcohol and at one sizes. CBD is currently being tested as a supportive treatment for alcohol withdrawal. 

Read More…

• Non-psychoactive cannabis ingredient could help addicts stay clean

• Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder

Other Liver Diseases That CBD May Be Effective In Treating

• Liver Cancer: Many metastases of different cancers develop inside the liver.
• Wilson’s Disease: An inherited disease that causes the body to maintain toxic copper in the bloodstream.
• Primary Sclerosing Cholangitis: An autoimmune disease that causes inflammation and obstruction of bile ducts.
• Primary Biliary Cirrhosis: An autoimmune disease of the small bile ducts.
• Budd-Chiari Syndrome: Liver vein obstruction.
• Glycogen storage disease type II: Increased glycogen levels to weaken muscles and affects the heart, liver skeletal muscles and central nervous system.

Gilbert’s Syndrome

An inherited disorder that manifests itself at a higher than normal level of bilirubin in the blood (hyperbilyrobinemia), which may cause the appearance of symptoms of mild jaundice which does not require treatment. The syndrome was first described in 1901 by a French gastroenterologist named Augustin Nicolas Gilber, and was named after him.

The disorder exists in about 5% of the population. The disorder is caused by a deficiency in the glucoronyl transferase enzyme found in the liver and its function is to pair bilirubin and other lipophilic molecules into a sugar molecule, which increases their solubility and allows them to be evacuated through the liver through bile juice to the stool.

As a result of the poor activity of the enzyme, bilirubin does not vacate quickly enough from the body and its blood level increases so that there is often mild jaundice. Other than that, no other symptoms were found. cardiovascular effect: Several studies have found a significant reduction in the risk of coronary heart disease and atherosclerosis in people with gilbert syndrome. These results have also been confirmed in the headquarters of studies.

Haemochromatosis

There includes a variety of different diseases, most of them congenital and some acquired, in which there is a disorder in iron metabolism. The accumulation of excess iron in various tissues causes impairment of their functioning. For example, iron build-up in the liver can lead to liver hayetics, iron build-up in the heart muscle can lead to cardiomyopathy, arthritis, as well as diabetes and damage to the sexual system (a condition called hypogonadotropic hypogonadism).

Haemochromatosis can arise from hereditary diseases (e.g. one caused by a mutation in a gene called HFE) or as a result of secondary causes that lead to iron accumulation in tissues, such as thalassemia, anemia for various reasons, excess iron in the diet, chronic liver disease, Porfirya disease, and other conditions that lead to excess iron.

Summary – CBD And Treatment Of Liver Diseases

It has been found that the endocannabinoid system works in an increased way during chronic liver diseases and is also involved in the development of diseases in the liver:

• Cannabidiol has an effect that protects liver cells and lowers fat levels in the liver.
• Soothing inflammation and antioxidant activity also benefits improve liver function.

CBD has been found to help treat liver diseases by eliminating hepatic stellate cells (HSC), which cause tissue scarring (fibrosis), and finally cannabidiol has been found to be effective in reducing nerve damage to cells and suppressing inflammation of the liver tissue as a result of impairment due to drinking alcohol or not as a result of alcohol.

Treating CBD for liver diseases or as a preventive treatment for liver diseases may be the best alternative. Further studies in the field of liver disease are currently underway and we will update the results.

Read More… CBD wins orphan drug status for autoimmune hepatitis