Cannabigerol (CBG) – Impacts and Therapeutic Qualities

An examination of the research released thus far indicates that cannabigerol boasts a broad spectrum of therapeutic benefits:

1. Safeguarding neural cells: Cannabigerol protects the brain’s neuroprotective cells from damage, malady, or decay. A study to validate this claim involved mice inflicted with Huntington’s disease (HD) who were administered controlled amounts of CBG. Following this, there was a deceleration in the damage to their neural system cells, effectively halting further degeneration and cell decay. Diseases that necessitate the safeguarding of neural cells include Alzheimer’s Disease (AD), Parkinson’s Disease (PD), Multiple Sclerosis (MS), individuals who have suffered a stroke, and those diagnosed with Huntington’s disease.
2. Potent antioxidant property: All phytocannabinoids possess powerful antioxidant qualities. Consequently, CBG also exhibits a robust antioxidant attribute and may assist in clearing brain tissue of free radicals.
3. Potential for addressing inflammation and discomfort: CBG showcases anti-inflammatory traits and could be an impactful adjunct in managing chronic infections. Superior to THC as an analgesic: Some research findings illustrate CBG’s main pain-relieving characteristic over THC. The cannabigerol activates the CB2 receptors and inhibits the TRPM8 cation channel, contributing to pain mitigation. Furthermore, CBG stimulates the alpha2-adrenoceptor adrenal receptor and impedes the 5-HT1A receptor. Pain, a concoction of physical and mental indicators, is more effectively managed by dual receptor stimulation, akin to the case of 2ARα and 5-HT1A.
4. Relieving muscle spasms and persistent lower back discomfort: The increased inhibition of GABA absorption by cannabigerol (surpassing THC and CBD) may offer relief from muscle spasms often experienced by muscular sclerosis patients, persistent lower back aches and sports-related injuries. 
5. Inflammatory bowel condition and digestive relief: A study that focused on the impact of CBG on the gastrointestinal system included testing on mice with colitis. The administration of CBGA reduced nitric oxide release (a promoter of inflammation) from immune cells in the gut. Consequently, CBG treatment lessened inflammation in the intestinal lining and improved gut health. 
6. Antibacterial action: Additional, comprehensive research suggests that CBG exhibits antibacterial and antimicrobial characteristics.   The CBG has proven effective in treating MRSA antibiotic-resistant bacteria as well as some other types of infections
7. Appetite enhancer: Research indicates that CBG boosts appetite and may alleviate symptoms stemming from chemotherapy. Moreover, a wealth of individual testimonies suggests CBG possesses a potent anti-nausea attribute.
8. Reducing intraocular pressure: Through both scientific studies and the gathering of personal anecdotal evidence, CBG exerts an impact on lowering intraocular pressure (IOP) in patients with glaucoma.
9. Reducing hypertension: CBG can decrease mental strain and irritation while lowering elevated blood pressure, enhancing working memory and cognitive supervisory functions. When operating optimally, the chance of experiencing depression, which is often paired with raised blood pressure, is lessened.
10. Possesses the vastest therapeutic potential in addressing depression: CBG exhibits an antidepressant characteristic. In a study to substantiate this, mouse brain membranes were treated with CBG. The cannabigerol stimulated the alpha2-adrenoceptor receptor and obstructed the receptor5-HT1A. The same results were observed in lab rats, revealing decreased anxiety and improved depressive symptoms.
11. Restricts the absorption of GABA and serotonin in the brain: Recent discoveries indicate that CBG can hinder the absorption of GABA and serotonin in the brain, potentially elevating levels of these two neurotransmitters. Research has associated low quantities of GABA and Serotonin with depression; thus, supplementing with external cannabinoids like CBG to assist and recalibrate the Endocannabinoid System presents a novel approach to managing depression—Cannabinoid Regulation of Fear and Anxiety: a Progress Report.
12. Boosts anandamide production: Most phytocannabinoid researchers believe that CBG notably amplifies the production of anandamide, an endogenous cannabinoid often referred to as the “internal bliss molecule.” A 2015 study involving humans and mice revealed that heightened levels of anandamide aid in mood enhancement and reduction of fear and anxiety. When the breakdown of anandamide was inhibited (by phytocannabinoids like CBD, etc.), a significant decrease was observed in fear and anxiety responses to environmental threats.