Frequently Asked Questions
The questions and answers before you include the most basic, common and important information. We have collected over the past few years in meeting with consumers (sick and healthy), manufacturers, breeders and researchers.
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Picture callout: Endo-cannabinoid is produced in the post-synaptic nerve cell while the appropriate receptor is found in the presynaptic nerve cell. In nerve cells that release the soothing neurotransmitter Gama Amino BUTIRIC Acid Gaba the cannabinoids will prevent (suppress) further release of the soothing neural messenger and thus the overall effect will be stimulating.
In nerve cells that release the stimulant neurotransmitter GLUTAMATE Glu the cannabinoid will suppress and prevent the release of the stimulant neurotransmitter and thus the overall effect will be soothing. The endo-cannabinoid system in the human body serves as a menstruary, and its main function is to bring the body and mind into balance— homeostasis. It is this balance that allows the body to work in the most healthy way. When the person consumes the Phyto-cannabinoids (from the cannabis plant) in smoking evaporation or eating, the Endo-Cannabinoid System in his body is “flooded” with “external” cannabinoids.
Despite the obvious differences in their chemical structure, both endo-cannabinoids (inside our bodies) and some of the Phyto-cannabinoids (which come from the plant) are associated with the same receptors in our bodies. (This is a rare phenomenon that does not yet have a comprehensive scientific explanation) The THC molecule is associated with a high affinity with CB1 and CB2 receptors, while CBD has not been linked to them at all – and its mechanisms of action differ and are not related to these receptors.
CBD is a Phyto-cannabinoid that is a trapeno-phenolic molecule made of 21 carbon atoms, which is formed as a result of de-carboxylation (co² heating in the presence of oxygen) from the substance of origin cannabidiolic acid (CBDA) and is not linked to the receptors of the CB1 or CB2 system but acts through a large number of other mechanisms of action that are recently revealed in the scientific study.
Cannabidiol does not cause intoxicating effects (Non-Intoxicating) and does not feel the feeling of elation (High) in its effect at all. On the contrary, cannabidiol has a calming general effect, which prevents anxiety and psychosis while simultaneously suppressing inflammation throughout the body and soothing pain, nausea and vomiting.
Hemp is a cannabis plant that contains high concentrations of CBD and extremely low concentrations of THC – up to 0.3% and is legal and approved for use in many countries (and their number is steadily increasing), so most of the oils containing CBD currently on the market are derived from the hemp plant.
CBD can be produced completely synthetically, from substances unrelated to the cannabis plant. Theoretically, CBD can be transformed into THC under laboratory conditions, but this reversal is inseparable (in terms of intolerant effect) in patients who consume CBD in normal digestive processes, in any way possible consumption (smoking, swallowing, evaporation, etc.).
The anti-inflammatory properties of CBD have been shown in many clinical studies as well as in cultured cells and many mechanisms of action have been exposed that work concurrently on about 60 different target proteins (receptors, ion channels, carrier proteins and enzymes) and therefore cannabidiol is considered a “per permitous drug”. Modern medical sciences and pharmacisms prefer a drug that is not a thyroid, that is, one molecule and a single target protein, thus also manifesting the lack of many drugs. (The body develops resilience, dependence and addiction)
In contrast, in 2017, the World Health Organization (WHO) determined that CBD is not toxic, has no intoxicating effects, and does not cause a feeling of obstetrics.
He added that CBD is a potentially non-dangerous drug, safe to use and has few possible side effects. Dozens of countries around the world are already in the process of changing national control in order to obtain CBD oil as a medical product. To date, there is no evidence of the use of CBD for recreation of “criminal” social use or abuse and the creation of dependence, and no public health problems and morbidity associated with the use of CBD have been found.
Cannabinoids (CBD) affect the human body as a result of linking to Endocannabinoid receptors (internal) across the membranes of different cells.
Two Endo-cannabinoid receptors are known:
- CB1 (central) found in the brain and nervous system at high concentrations.
- CB2 (peripheral) found mainly in the periphery and immune cells.
Our bodies have Endo-cannabinoids that are naturally produced molecular compounds in the body. Endo-cannabinoids bind and activate the two cannabinoid receptors in our bodies.
The Best Known Are:
Anandamide – Aedeid Ethanol
Archidonil (AEA)
Arachidonil Glycerol – (2-AG)
Despite the obvious differences in their chemical structure, both Endocannabinoids and some Phyto-cannabinoids bind to the same receptors in our bodies:
THC has been associated with high affinity for CB1 and CB2 receptors while CBD has not been linked to them at all and its mechanisms of action differ and are not related to these receptors.
The pharmacological activity of the CBD is very interesting. Although it does not work directly on CB1 and CB2 receptors, it has the ability to block the activity of certain compounds that activate these receptors, such as THC. This trait of CBD is important as it may suppress the psychoactive effects of THC which may be beneficial for those who use THC to treat pain and convulses. Reducing the psychoactive effect will reduce the side effects of THC and medicinal cannabis and this balance can be maintained by providing CBD as a supplement to the medical prescription.
Today there is much evidence that supports the theory of “clinical Endo-cannabinoid missing” (Dr. Eitan Russo) mainly in diseases such as migraine, PTSD, fibromyalgia, and irritable bowel syndrome. CBD and CBDA are considered compounds that balance this system in the most effective way, and the evidence of their many healing abilities and properties only increases by the day. Studies dealing with CBD and CBDA occur at any given moment and a large number of pharmacological targets have already been revealed.
Inhibition of the decomposition of Endocannabinoids
The enzyme FATTY ACID AMIDE HYDROLASE – FAAH breaks down anandamide and 2-AG and thus ends their operation with synapse quickly. Cannabidiol inhibits this enzyme (FAAH) and thus increases the pain-soothing and soothing activity of Endocannabinoids through the endocannabinoid receptors. Fatty acid amide hydrolase
(FAAH is an enzyme responsible for the activity of the anandamide. CBD inhibits the activity of this enzyme.
In this way the CBD returns the anandamide to a normal level (by stopping the decomposition), and returns the endo-cannabinoid system to balance. A medical study examining the effect of CBD on schizophrenia patients showed that cannabidiol caused an increased increase in anandamide levels, resulting in medical improvement in those patients.
Antioxidant activity
Activity against REACTIVE OXYGEN SPECIES ROS which damage cells in different tissues and stimulate inflammatory processes and pain. The U.S. government’s patented listing of cannabidiol’s antioxidant properties can be found in the following link:
Cannabinoids as antioxidants and neuroprotectants
Anti-inflammatory activity
Activity manifested in suppression of cytokine release (CYTOKINES) and interleukines, which encourage inflammatory processes from immune cells.
Action of receptors
The action of receptors in cell nuclei Peroxisome Proliferator-Activated Receptors (PPARS) and transcription factors that monitor the expression of many PPARS genes expressed on the cell nucleus envelope, Monitors the development, differentiation, metabolism of carbohydrates, proteins and fats, as well as malignant cancer processes. Cannabidiol activates PPARS and prevents the development of malignant cells and the formation of harmful proteins (AMYLOID PLAQUE BETA) in the brains of Alzheimer’s disease patients. , including inflammation of the brain and digestive system.
Operation and opening of underage canals
TRANSIENT RECEPTOR POTENTIAL VANNILOID = TRPV-1 responsible for recession of pain, body temperature and inflammation. The action of this receptor/ion canal by CBD calms the feeling of pain, suppresses inflammatory processes and lowers body temperature.
Activating the 5HT1A clone receptor
(Hydroxy tryptamine serotonin receptor) affects as an antidepressant, nausea and anxiety. This effect is intensified by the activation of the Adenosine receptor by CBD. It is important to emphasize that cannabidiol has not been associated at all with other syotronergic receptors like 5HT2A or 5HT3A that cause hallucinations.
The action of the “orphaned” receptors
Which are: GPR18 GPR55 GPR119 =G PROTEIN BINDING RECEPTOR.
In conclusion – CBD intake allows those internal cannabinoids to remain in our bodies for longer, which supports and strengthens the Endocannabinoid System.
Adults: If you are in a high-risk medical condition and are taking medications with serious side effects, consult your physician before using CBD.
Children: We do not in any way recommend taking cannabis by those who are not 18 by law. Studies of medicinal cannabis are inconclusive regarding its possible effects on the development of the brain and central nervous system on children who are still in the developmental stage of their bodies, while using cannabis. Although CBD is not intoxicating, it is not true to say that it has no psychoactive effects. Taking CBD by minors should be carried out while consulting a doctor and with the sole responsibility of the parent.
Pregnant women: We do not in any way recommend taking CBD during pregnancy. Despite the CBD’s high “safety profile”, no studies have yet been carried out on the subject and without denying any possibility of possible damage to the foetus – there is no need to take unnecessary risks. Perhaps this is the place to note that there is a severe negative effect of THC on the brain development of the foetus.
Animals: In most animals there is an endocannabinoid system that is responsible as in man for the balance between body and mind. The mechanisms of action of CBD in animals are the same as the mechanisms of action of the person and therefore the effect of CBD on animals will be beneficial and desired mainly for animals with inflammation, joint pain and aging. However, insufficient studies have yet been done on the effect of CBD on animals, the desired dose according to body weight, etc., and therefore any treatment of animals is required in consultation with a veterinarian. It’s worth knowing that dog breeds are very sensitive to cannabinoids because of their genetic makeup.
You should be aware of the possible side effects before putting CBD into our diary routine. While the possible side effects are minimal, it is important to remember that the substance may affect everyone in a different way, and what happens to one will not necessarily happen to another, so it is important to start with a low dose that increases gradually. Here’s how to notice side effects, if any, and reduce the dose back if there are one or more of the following side effects:
Thirst or dry mouth: A study conducted in 2006 indicates that cannabinoid receptors are also found in cells that secrete salivary fluid, so that when CBD affects the activity of the endo-cannabinoid system the salivary glands have difficulty forming saliva.
Decrease in blood pressure: When taking CBD at high doses, there is a chance of a decrease in blood pressure. It is recommended to consult a doctor before consuming CBD oil in case of blood pressure problems or in combination with medications to regulate blood viscosity.
Drowsiness and provocation: Because CBD consumption affects different people differently, arousal or drowsiness are possible side effects in the first few days of use of the product. In case CBD consumption causes drowsy, avoid running heavy equipment or driving, and it is recommended to reduce the dose to a level that does not cause drowsy in the middle of the day.
NO! It will cause alertness, vitality and energy, but it has no effect on the brain that is the same as the effect of THC.
The CBD first and foremost provides relief. Both mentally and physically.
Relief from pain and relief from distress. In truth, many are surprised that the CBD doesn’t give a sense of intoxication. For years of warnings about the “toxicity” of cannabis and marijuana – but the CBD is neither foggy nor intoxicating. You can take the regular dose and start your daily routine.
It is important to note that although CBD is not intoxicating, it is defined as psychoactive and acts on the nervous system in a variety of ways.
Both marijuana and hemp have several hundred other active substances – cannabinoids, flavonoids and terpenes. The same molecules in marijuana also have in Hamp. The difference is in the amount of molecules, that is, in the molecular composition.
The confusion stems in part from the fact that in recent years a dietary supplement called Hemp Oil, or Hemp Seed Oil, has reached the shelves. Hemp oil is made from seeds where there are no cannabinoids at all. Not CBD and not THC.
There are people whose question stems from rumours (fundamentally true) that the name of the hemp, which is not raised and manufactured under conditions suitable for medical consumption, floods the market with inferior products.
Therefore, CBD products must be purchased from a recognized company, which transparently provides the information about the contents of the product and operates under the GMP standard
Hemp oil is not always written – sometimes the CBD is used in olive oil or coconut oil.
The manufacturers’ choice of CBD-issued carrier oil is related to a variety of considerations such as taste, price, shelf life and more.
manufacturer, who publishes product analyses on his website, one must first understand that the amount of CBD in the product is measured in milligrams and the amount of liquid in the bottle is measured in millilitres.
2000mg in a bottle of 10 0 0 0 000 000% CBD.
2000mg in a 20 10% CBD bottle is a concentration.
See table:
Over time, the public began to ask for the oils/inflorescences in which the percentage of CBD was relatively high (15%) but in terms of medicinal cannabis it was about “Indica” strains in which the CBD is high but there is also a concentration of THC ranging from 5% to 1%.
CBD products are made from the hemp plant because the percentage of THC is less than 0.3%. (And of course as an economic consideration in light of the higher the percentage of CBD BHP).
The transition from products with 1% or more THC to products with less than 0.3% THC does not eliminate the need for THC and its importance in future healing and research processes, but at the same time we see this transition as the possibility of bringing a very broad public into the healing cycle of cannabis and to familiarize ourselves with its unique properties.
What does hemp seed oil contain?
Hemp seed oil contains very important supplements, amino sourness and omega-3-6. It can and should be added in many ways to the daily menu of the average family, but it is important to know that it does not have all those substances that distinguish cannabis (in this case hemp) from the other existing plants.
Hemp seeds, on the other hand, do not contain CBD, nor THC, nor the other hundreds of substances in the plant’s other actives, so they do not participate in the extraction process.
Next, the product itself is “building”: a certain concentration of CBD and the rest of the cannabinoids are underlying (or loaded onto) some essentially neutral oil. These oils are well-known oils in the food, cosmetic and pharmaceutical industries. This oil can be hemp oil (the one that isolated the CBD)or olive oil or MCT medical coconut oil.
Some patients report some dry mouth and/or thirst, sometimes with excessive arousal until bedtime and difficulty falling asleep. These side effects are generally easy to treat by lowering the dosage.
Other possible side effects can be found in the list in our professional blog.
It is important to know how to answer the following questions when trying to understand the legality of CBD:
- What is the source (country, factory, company) from which the CBD is produced
- What are the laws about cannabis in the country where you live?
- Are these laws expected to change soon?
Recently the CBD has become increasingly interested in scientific research devoted to the subject. As a result, the legal status of the CBD varies frequently around the world. It is recommended to keep up to date with state laws from time to time. It is important to note that everything written on the site should not be seen as legal advice regarding the legality of the material in the country in which you reside. Our CBD products are derived from the hemp plant and do not contain more than 0.3% THC so they are perfectly legal in most countries of the world.
The truth is not that – CBD does not become THC in the stomach.
Extensive clinical studies show that CBD ingestion – even doses above 600g – do not cause psychoactive effects of THC. On the contrary – CBD in sufficient quantities may reduce or neutralize the feeling of THC introduction. The World Health Organization (WHO) studied the issue three years ago and gave CBD full health approval and its 2017 report: “Pseudo gastricfluid does not exactly replicate gastrointestinal physiological conditions and reversal of CBD to THC has not been proven in people undergoing CBD treatment.”
But if you don’t like the taste hemp oil has and prefer to consume CBD in a more measured way, CBD capsules can be a good answer to what you’re looking for.
Alternatively, if you prefer to avoid ingesting CBD (if you have local pain for example), then CBD products like analgesic ointments or CBD candles can be a good solution for you.
- Taking under the tongue
- Ingesting CBD integrated into food products
- Inhaling CBD by evaporating
- Applying CBD to skin
- CBD candles for vaginal or rectal taking.
The most common form of CBD is oral, by dripping droplets of oil under the tongue, or
in combination with drinking or food.
It is recommended to avoid ingesting the oil for as long as possible, in order to allow it to be well absorbed in the motus of the mouth. Its absorption through the stomach will take longer and may even slightly impair its effect.
The World Anti-Doping Agency (WADA) – which is responsible for controlling the use of banned substances at the Olympics and is considered the body that sets doping policy in sports leagues around the world, announces that from 2018 the CBD will no longer be considered a banned drug.
Young cannabis consumers may be far from disturbing thoughts about the future – but people who have gone through their youth take into account a future of physical limitations and disease and therefore, if they want to avoid it , bone health is the basis and center. Of course, proper nutrition and
exercise are essential, and we now know that the endo-cannabinoid system – a concept that has been increasingly exposed in recent years – participates in all its other functions in bone strengthening and recently quite a few studies have shown the effectiveness of CBD in helping to mend bones.
The rate of the effect of the substance on the body varies according to a number of main factors – the method of use, frequency of use, body weight, metabolic rate in the body and of course the typeand quality of the CBD product you use.
CBD products have already received the recommendations of many veterinarians. A growing number of veterinarians believe that cannabidiol (CBD) products can be effective in treating a variety of diseases in dogs and cats, from treating anxiety, inflammation and infections from joint imbalances, the effects of old age, to lack of appetite. Although the doses that humans and animals like dogs and cats take, are not the same, CBD can be used to treat the same conditions in pets in the same way it is used to treat humans. Due to the great similarities between our body systems and that of dogs and cats, who are also mammals.
It is important to note – There are some types of dogs that do not respond well to CBD. You can read on our professional blog about the types of races and the latest scientific information on the subject.
Many people who consume psychiatric prescription drugs use CBD as a solution to anxiety, depression, etc. We do not recommend discontinuing the consumption of these prescription drugs without consulting the attending physician however many users report that the CBD does not interfere or conflict with the medications they are taking.
A list of the labels for caution in the use of CBD can be found on our website.
But someone who is young and healthy and does not suffer from any chronic pain – what will CBD help him?
On our home screen you can enter the quality of life category and be impressed by the variety of virtues that cannabidiol brings to young people who come to the world of cannabis from a different angle.
CBD inflorescence has many medicinal benefits and can be used as a substitute for tobacco for those who wish to quit smoking nicotine, however those who want to gain the most medical effects of CBD should consider using oil, in redness and other effective ways.
THC is abundant in some non-hemp cannabis strains, while CBD is found in high concentrations in hemp plants rather than marijuana. In growing non-hemp cannabis, we try to maximize THC concentrations in order to increase the intoxicating psychoactive effects. The concentration of THC in Hamp is very low, and in fact CBD is the most concentrated active substance in hemp plants. For a cannabis plant to be classified as hemp, it must contain THC at a dose less than 0.3%. The main difference between the two compounds is how they affect us.
The difference in molecular structure affects how the different molecules bond with the endo-cannabinoid system receptors found in our bodies. And in plain language THC causes a feeling of intoxication but CBD does not. The THC stimulates a reaction in the CB1R colotin of the ECS system located mainly in the central nervous system and in the brain.
Psychoactive effects: Activating these receptors has a psychoactive effect. On the other hand, CBD does not activate these receptors, and therefore does not affect perception or sensory experiences. In fact, studies show that CBD intake combined with THC reduces the psychoactive and frenetic effects of THC by reducing the link to CB1R receptors and actually protecting the user from severe highs.
Social anxieties: Scientific studies show that CBD may help sufferers of social anxiety or panic attacks. Conversely, high-dose THC can sometimes trigger anxiety in some people, as other studies show.
Retention of sperm cells: Studies examining the combined effect of both substances show that CBD intake in addition to THC intake moderates the psychoactive effects of THC and it was also recently discovered that isolated THC may damage the hereditary substance Saturn and CBD presence prevents these damages.
With the exception of relatively few cases, fibromyalgia does not appear on the Ministry of Health’s labeling list for medical cannabis licenses Most fibromyalgia patients who have experienced CBD products report a significant improvement in symptoms, indicating that CBD helps them function and manage daily routines.